<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PL19326 69880 Portugal 2001 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 NFV+ RTV+ IDV+ 3TC+ D4T+ AZT NA
2 NVP+ 3TC+ AZT NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V   V106A   V35T, T39L, A98S, K101KQ, K122E, D123S, I135T, T139TR, K173R, Q174K, D177E, Q207K, R211S, V245Q, E248D, D250E, A272P, K275Q, K277R, T286A, E291D, V292I, I293V, D320E, D324E, I329V, Q334L  
>69880| codons 1-335
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICLEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLQKKKSATVLDVGDAYFSVPL
DESFRKYTAFTIPSTNNERPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRKNPEIVI
YQYVDDLYVGSDLEIGQHRTKIEELRKHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIQVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYEPSKELIAEVQKQGLG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90LM   I13V, K14R, K20I, E35D, M36I, R41K, K43KR, R57K, L63Q, I64M, H69K, V82I, L89M  
>69880| codons 1-99
PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLEDINLPGKWRPKMIGGIGGFIKVKQYD
QIQMEICGKKAIGTVLVGPTPINIIGRNMMTQIGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005