<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA641 CA3111 U.S. 1997 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 104
2 AZT+DDI 117
3 3TC+AZT 31
4 3TC+AZT+IDV 26
5 3TC+D4T+IDV 27
6 3TC+D4T+RTV+SQV 9

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67DN, T69AD, M184V, L210W, T215Y       K20R, V35M, T39S, K43E, E44D, V118I, K122E, V179VI, T200A, E203K, Q207D, H208Y, R211K, K223E, L228H, A272P, K277R, T286A, I293V, E297K  
>CA3111| codons 1-303
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICSELEEDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII
YQYVDDLYVGSDLEIGQHRAKIKELRDYLWKWGFYTPDKKHQEEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTKEAE
LEL

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32VI, M46MI, V82VA L33IV, F53FL, L89V L10I, N37C, L63P, A71AV  
>CA3110| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTIVEEMCLPGRWKPKIIGGIGGLIKVRQYD
QIPIEICGHKVIGTVLVGPTPANIIGRNVLTQIGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005