<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PL8884 65233 Portugal 2001 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 SQV+ IDV+ NVP+ 3TC+ DDI+ D4T NA
2 LPV+ EFV+ ABC NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, T215Y K219E K101AE, Y181C, G190A P225PH V35T, T39TI, K43R, V60I, S68G, V90VI, A98S, K103KR, K122E, D123S, I135T, K173R, Q174K, D177E, T200A, Q207K, R211S, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297A, V317A, D320N T165IM
>65233| codons 2-320
ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICIELEREGKISKIGPENPYNTPIF
AIKKKDGTKWRKVVDFRELNKRTQDFWEIQLGIPHPSGLAKRKSVTVLDVGDAYFSVPLD
ESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRRKNPEIVIC
QYMDDLYVASDLEIGQHRAKIEELRKHLLSWGFYTPDEKHQKEHPFLWMGYELHPDKWTV
QPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAEL
ELAENREILKEPVHGAYYN

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, L90M F53L, L89V L10I, I13A, K14R, I15IV, K20I, E35D, M36I, R41K, Q61QH, L63P, H69K, A71IT, V82X, T91TS  
>65233| codons 1-99
PQITLWQRPIVTARVGGQLIEALLDTGADDTVLEDINLPGKWKPKIIGGIGGLVKVRQYD
HIPIEICGKKIIGTVVVGPTPXNIIGRNVMSQIGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005