Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1173 | CA3100 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 283 |
| 2 | DDI | 113 |
| 3 | 3TC+AZT | 22 |
| 4 | 3TC+AZT+SQV | 57 |
| 5 | 3TC+D4T+IDV | 25 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A | L10I, V77I |
| >CA3100| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIVGIGGFVKVRQYD QILIEICGHKAIGTVLIGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219Q | T27S, I31V, K64H, T69N, K122E, I195L, D218E, L228H, V245M, E248V, K249Q, A288T, I293V |
| >CA3099| codons 1-298 PISPIETVPVKLKPGMDGPKVKQWPLSEEKVKALVEICTEMEKEGKISKIGPENPYNTPV FAIHKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLELGQHRTKIEELRQHLLRWGFTTPEQKHQKEPPFHWMGYELHPDKWT VQPIMLPVQDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKTLTEVVPLTEE |
References
| Author | Title | Citation |
| Zolopa, AR | HIV-1 genotypic resistance patterns predict response to saquinavir/ritonavir in patients in whom previous protease inhibitor therapy failed. | Ann Intern Med, 1999 |
| Rhee, SY | Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing. | AAC, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |