<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PL36069 59512 Portugal 2001 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 DDC+ AZT NA
2 3TC+ D4T+ NFV NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, T215Y       V35T, T39TI, V60I, A98S, K122KE, D123NS, I135T, K173I, Q174K, D177E, T200A, Q207E, R211S, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292VI, I293V, E297A, D320E, D324E, I329V, Q334P  
>59512| codons 1-335
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICIELEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEIVI
YQYVDDLYVGSDLEIGQHRAKIEELREHLLSWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTAEAE
LELAENREILKEPVHGVYYEPSKELIAEVQKQGPG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, L90M   I13V, K20I, E35N, M36I, N37ND, R41K, H69K, T74S, V82I, L89I  
>59512| codons 1-99
PQITLWQRPLVTVKIGGQLIEALLDTGADDTVLENIDLPGKWKPKMIGGIGGFVKVRQYD
QILIEICGKKAIGSVLVGPTPINIIGRNIMTQIGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005