<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PL405 55413 Portugal 2001 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ NFV+ SQV+ IDV+ NVP+ 3TC+ DDC+ DDI NA
2 EFV+ DDC+ D4T NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90LM   I13V, K14R, K20I, E35D, M36I, R41K, I62IV, H69K, V82I, L89M  
>55413| codons 1-99
PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QVLIEICGKKAIGTVLVGPTPINIIGRNMMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, V75T, T215Y K219E K103N, Y181C, G190A   V35T, K43R, V60I, T69N, A98S, K101Q, K122E, D123N, I135T, R172RK, K173I, Q174K, D177E, I178IM, T200A, E203K, Q207E, R211NS, D218DE, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297A, D324E  
>55413| codons 1-324
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEREGKISKIGPENPYNTPI
FAIKKKNSNRWRKLTDFRELNKRTQDFWEVQLGIPHPSGLQKNKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKIKNPEMVI
CQYMDDLYVASDLEIGQHRAKIKELREHLLNWGFYTPEEKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAE
LELAENREILKEPVHGVYYDPSKE

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005