<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1274 CA3059 U.S. 1997 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 187
2 AZT+DDC+SQV 100
3 3TC+DDI 20
4 3TC+D4T+IDV 23
5 DDC+RTV+SQV 20
6 AZT+DLV+NFV+SQV 11

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90M Q58E, G73S L10I, I15V, K20M, M36I, I62V, L63P  
>CA3059| codons 1-99
PQITLWQRPIVTIKVGGQLMEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVREYD
QVPIEICGHKAISTVLVGPTPVNIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70GR, T215F K219Q K103N   K102Q, K122E, I135V, D177X, G196E, I202X, E248D, A272G  
>CA3060| codons 1-287
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSTGWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPXIVI
YQYMDDLYVGSDLEIEQHRTKXEELRQHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYGGIKVKQLCKLLRGTK

References
Author Title Citation
Shulman, NS Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: Clinical and genotypic predictors of virologic response. JAIDS, 2000
Kantor, R Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy. AAC, 2002
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005