Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt36 | pt36-t1 | Italy | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | NA |
| 2 | AZT+ DDC+ IDV | NA |
| 3 | 3TC+ AZT+ IDV | NA |
| 4 | D4T+ DDI+ RTV+ SQV | NA |
| 5 | 3TC+ D4T+ RTV+ SQV | NA |
| 6 | AZT+ DDI+ EFV+ NFV | NA |
| 7 | AZT+ DDI | NA |
| 8 | ABC+ DDI+ RTV+ SQV | NA |
| 9 | 3TC+ AZT+ LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | G73C | L10I, I62V, L63P, I66IL, H69K, V77I |
| >pt36-t1| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD QVPIELCGKKAICTVLIGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74I, M184V, T215F | D67H, K219Q | K20R, T69N, K101KQ, L109V, K122KE, D123DE, I142T, S162C, E169D, I178L, H208Y, R211K, D218E |
| >pt36-t1| codons 1-230 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKHSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVVDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPDLVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLLKWGFFTPEQKHQKEPPFLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |