Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt35 | pt35-t1 | Italy | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | AZT+ DDI | NA |
| 3 | 3TC+ AZT | NA |
| 4 | 3TC+ AZT+ SQV | NA |
| 5 | D4T+ DDI+ SQV | NA |
| 6 | D4T+ DDI+ IDV | NA |
| 7 | D4T+ DDI+ NFV | NA |
| 8 | D4T+ DDI+ EFV | NA |
| 9 | D4T+ DDI+ LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | L10I, T12S, L19T, K20IM, I62V, L63S, A71T, V77I |
| >pt35-t1| codons 1-99 PQITLWQRPIVSIKIGGQTMEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QVSIEICGHKTIGTVLIGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | L100LI, K103KN | K20R, K43Q, V118I, K122E, D123DN, I135T, I202V |
| >pt35-t1| codons 1-230 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKVEELRQHLWRWGFYTPDKKHQKEPPFLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |