Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1271 | CA3050 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | DDI | 52 |
| 3 | D4T | 100 |
| 4 | 3TC+AZT | 35 |
| 5 | 3TC+AZT+IDV | 22 |
| 6 | 3TC+D4T+IDV | 13 |
| 7 | 3TC+D4T+IDV+NVP | 4 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | G190A | K20R, T39A, E44D, V118I, K122E, I135T, D177E, E203K, H208Y, R211D, L283I, R284K, I293V |
| >CA3050| codons 1-302 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVASDLEIGQHRTKIKELRQYLWDWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIKGTKALTEVVPLTEEAE LE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V | G73C | E35D, N37E, R41K, L63P, K70T, V77I, I93L |
| >CA3051| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTILEDMELPGKWKPKMVGGIGGFIKVRQYD QIPIEICGHTAICTVLIGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Zolopa, AR | HIV-1 genotypic resistance patterns predict response to saquinavir/ritonavir in patients in whom previous protease inhibitor therapy failed. | Ann Intern Med, 1999 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |