Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt18 | pt18-t0 | Italy | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | AZT+ DDC | NA |
| 3 | AZT+ DDC+ SQV | NA |
| 4 | 3TC+ AZT+ SQV | NA |
| 5 | 3TC+ D4T+ IDV | NA |
| 6 | D4T+ DDI+ RTV+ SQV | NA |
| 7 | D4T+ DDI+ EFV+ NFV | NA |
| 8 | 3TC+ AZT+ IDV+ RTV | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K219R | Y188L | V179VD | K43Q, E44D, V106VI, V118I, K122P, D123E, S162C, D177E, I178L, T200K, Q207E, H208Y, R211K, K223Q, L228H |
| >pt18-t0| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DPEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPELDI YQYMDDLLVGSDLEIGQHRKKIEELREYLWKWGFYTPDRKHQQEPPFHWM |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | L33LI, Q58E, G73T | L10I, K20KR, E35D, M36I, I62V, L63P, A71V, P79D |
| >pt18-t0| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVIEDINLPGRWKPKMIGGIGGFIKVREYD QVPIEICGHKVITTVLVGDTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |