Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt33 | pt33-t0 | Italy | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T | NA |
| 2 | AZT+ DDI | NA |
| 3 | 3TC+ AZT+ SQV | NA |
| 4 | 3TC+ D4T+ SQV | NA |
| 5 | D4T+ EFV+ IDV | NA |
| 6 | 3TC+ D4T+ IDV | NA |
| 7 | D4T+ IDV+ NVP | NA |
| 8 | D4T+ DDI+ IDV | NA |
| 9 | D4T+ DDI+ RTV+ SQV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L33I, G73S | L10I, E35D, M36I, N37D, K45R, I62IV, L63P, A71V, I72IL |
| >pt33-t0| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVIEDIDLPGRWKPRMIGGIGGFVKVRQYD QVPIEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K103N | K20R, T39A, S48E, V60I, V118I, K122P, D123E, I135IV, D177E, Q207E, R211K, L228H |
| >pt33-t0| codons 1-230 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKIEKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DPEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFHWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |