Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt17 | pt17-t1 | Italy | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | DDI | NA |
| 3 | DDC | NA |
| 4 | AZT+ DDC | NA |
| 5 | AZT+ DDC+ SQV | NA |
| 6 | 3TC+ D4T+ RTV | NA |
| 7 | DDI+ EFV+ NFV | NA |
| 8 | D4T+ DDI+ LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54S, V82A, L90M | T4S, L10I, L19V, K20R, M36I, N37D, I62V, L63P, I64V, H69I |
| >pt17-t1| codons 1-99 PQISLWQRPIVTIKIGGQVREALLDTGADDTVLEEIDLPGRWKPKMIVGIGGFSKVRQYD QVPVEICGIKAIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, L210W, T215Y | D67E | K103N, Y181C, G190A | K101N | V35T, T39A, E44D, S68G, K82R, V118I, K122E, D123E, I135T, I142V, D177E, I178L, G196E, E204N, R211N |
| >pt17-t1| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKDGKISKIGPENPYNTPV FAIKKKEGTKWRKLMDFRELNRRTQDFWEVQLGIPHPAGLNKNKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPELVI CQYMDDLYVASDLEIEQHRTKIENLRQHLWNWGFYTPDKKHQKEPPFLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |