Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt32 | pt32-t0 | Italy | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | AZT+ DDC | NA |
| 3 | 3TC+ D4T | NA |
| 4 | 3TC+ D4T+ SQV | NA |
| 5 | 3TC+ D4T+ IDV | NA |
| 6 | D4T+ IDV+ NVP | NA |
| 7 | D4T+ NFV+ NVP | NA |
| 8 | None | NA |
| 9 | ABC+ DDI+ RTV+ SQV | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, L210W, T215Y | D67E | Y181C, G190A | V35I, K43E, E44D, S68G, V118I, K122P, I135T, A158S, D177E, V179I, T200E, I202V, E203K, Q207E, R211K |
| >pt32-t0| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEEDGKISKIGPENPYNTPV FAIKKKEGTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DPDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPEIII CQYMDDLYVASDLEIGQHREKVKELREHLWKWGFYTPDKKHQKEPPFLWM |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, V82C, L90M | Q58E | L10I, I62V, L63P, I64L, A71T, V77I, I93L |
| >pt32-t0| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIVGIGGFIKVREYD QVPLEICGHKTIGTVLIGPTPCNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |