Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt16 | pt16-t1 | Italy | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | NA |
| 2 | 3TC+ AZT | NA |
| 3 | 3TC+ AZT+ SQV | NA |
| 4 | 3TC+ AZT+ RTV+ SQV | NA |
| 5 | 3TC+ AZT+ NFV | NA |
| 6 | D4T+ DDI+ NFV | NA |
| 7 | DDI+ EFV+ RTV | NA |
| 8 | ABC+ DDI+ EFV | NA |
| 9 | 3TC+ D4T+ LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, L90LM | Q58QE, G73GA | L10LI, K20KR, N37D, I62V, L63P, I64L, A71T, V77I, I93L |
| >pt16-t1| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFIKVREYD QVPLEICGHKTIATVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L210W, T215Y | Y188YF | K43Q, K49R, K103KR, I135T, I202IV, R211RK |
| >pt16-t1| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISRIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLFVGSDLEIGQHRTKVEELRQHLWKWGFYTPDKKHQKEPPFLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |