Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt16 | pt16-t0 | Italy | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | NA |
| 2 | 3TC+ AZT | NA |
| 3 | 3TC+ AZT+ SQV | NA |
| 4 | 3TC+ AZT+ RTV+ SQV | NA |
| 5 | 3TC+ AZT+ NFV | NA |
| 6 | D4T+ DDI+ NFV | NA |
| 7 | DDI+ EFV+ RTV | NA |
| 8 | ABC+ DDI+ EFV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | Q58E, G73A | L10I, N37D, I62V, L63P, I64L, A71T, I72IV, V77I, I93L |
| >pt16-t0| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFIKVREYD QVPLEICGHKTVATVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | Y181C, Y188L | V179D | K43Q, K49R, V60VI, K103R, I135T, I202V, R211K |
| >pt16-t0| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISRIGPENPYNTPI FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIDI CQYMDDLLVGSDLEIGQHRTKVEELRQHLWKWGFYTPDNKHQKEPPFLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |