Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt31 | pt31-t1 | Italy | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | NA |
| 2 | 3TC+ AZT | NA |
| 3 | 3TC+ D4T+ IDV | NA |
| 4 | DDI+ NVP+ RTV+ SQV | NA |
| 5 | D4T+ DDI+ LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82C, I84V | Q58E | L10I, E35D, D60E, I62V, L63P, H69N, A71V, V77I, I93M |
| >pt31-t1| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMNLPGRWKPKMIVGIGGFVKVREYE QVPIEICGNKVIGTVLIGPTPCNVIGRNLLTQMGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W | T215C, K219E | Y181C | K101N | V35I, T39A, E40K, K43E, V60I, R83K, V118I, V179L, R211K, D218E |
| >pt31-t1| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAKLEEEGKISKIGPENPYNTPI FAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPAGLNKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDILI CQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFCTPEEKHQKEPPFLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |