<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
MZ-pt30 pt30-t0 Italy 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDC+ SQV NA
2 AZT+ SQV NA
3 3TC+ AZT+ SQV NA
4 3TC+ AZT+ IDV NA
5 3TC+ AZT+ RTV+ SQV NA
6 3TC+ AZT+ NFV+ SQV NA
7 AZT+ DDI+ NFV+ NVP NA
8 AZT+ DDI+ SQV NA
9 3TC+ ABC+ DDI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I84V, L90M G73C L10I, T12I, R41K, I62V, L63P, C67CF, V77I, I93L  
>pt30-t0| codons 1-99
PQITLWQRPIVIIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD
QVPIEIFGHKAICTVLIGPTPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, M184V K219Q K103KN   K49R, I50V, A98AS, K101KQ, K122E, I135T, D177G, R211RK, D218E  
>pt30-t0| codons 1-230
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISRVGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLQKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPEQKHQKEPPFLWM

References
Author Title Citation
Romano, L Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. JAIDS, 2002
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005