Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt30 | pt30-t0 | Italy | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC+ SQV | NA |
| 2 | AZT+ SQV | NA |
| 3 | 3TC+ AZT+ SQV | NA |
| 4 | 3TC+ AZT+ IDV | NA |
| 5 | 3TC+ AZT+ RTV+ SQV | NA |
| 6 | 3TC+ AZT+ NFV+ SQV | NA |
| 7 | AZT+ DDI+ NFV+ NVP | NA |
| 8 | AZT+ DDI+ SQV | NA |
| 9 | 3TC+ ABC+ DDI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | G73C | L10I, T12I, R41K, I62V, L63P, C67CF, V77I, I93L |
| >pt30-t0| codons 1-99 PQITLWQRPIVIIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QVPIEIFGHKAICTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V | K219Q | K103KN | K49R, I50V, A98AS, K101KQ, K122E, I135T, D177G, R211RK, D218E |
| >pt30-t0| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISRVGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLQKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPEQKHQKEPPFLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |