Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1269 | CA3046 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 69 |
| 2 | AZT+DDI | 109 |
| 3 | D4T | 13 |
| 4 | DDC | 35 |
| 5 | 3TC+DDC | 9 |
| 6 | 3TC+DDI+SQV | 18 |
| 7 | 3TC+DDI+IDV | 35 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V | K219Q | K104N, K122E, T200A, I202V, L228H, I257T |
| >CA3046| codons 1-274 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKVEELRQHLLRWGFTTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDTQKLVGKLNWASQIYAGI |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I13V, L19I, K43R, L63P, I64V, E65D |
| >CA3047| codons 1-99 PQITLWQRPIVTVKIGGQIKEALLDTGADDTVLEEMNLPGRWRPKMIGGIGGFIKVRQYD QIPVDICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |