Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt8 | pt8-t0 | Italy | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | AZT+ DDC | NA |
| 3 | 3TC+ D4T+ SQV | NA |
| 4 | 3TC+ D4T+ IDV | NA |
| 5 | D4T+ DDI+ EFV+ NFV | NA |
| 6 | D4T+ EFV+ NFV | NA |
| 7 | D4T+ DDI+ IDV+ NFV | NA |
| 8 | D4T+ DDI+ NFV | NA |
| 9 | ABC+ D4T+ DDI | NA |
| 10 | 3TC+ ABC+ DDI | NA |
| 11 | 3TC+ D4T+ APV | NA |
| 12 | D4T+ DDI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L33I, Q58E, G73S | L10I, E35D, M36I, R41K, K55R, I62V, L63P, A71V |
| >pt8-t0| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVIEDINLPGKWKPKMIGGIGGFVRVREYD QVPIEICGHKVISTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | L100I, K103N | K20R, V35I, K43N, E44D, V118I, K122E, D177G, H208Y, R211K, D218E, F227Y |
| >pt8-t0| codons 1-230 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGIVI YQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPENKHQKEPPYLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |