Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt7 | pt7-t0 | Italy | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | DDI | NA |
| 3 | AZT | NA |
| 4 | DDI | NA |
| 5 | AZT+ DDI | NA |
| 6 | DDC | NA |
| 7 | RTV | NA |
| 8 | AZT+ DDC+ SQV | NA |
| 9 | 3TC+ D4T+ IDV | NA |
| 10 | D4T+ DDI+ NFV | NA |
| 11 | D4T+ DDI+ EFV | NA |
| 12 | 3TC+ D4T+ EFV | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | K219N | G190E | E44D, A98S, V118I, K122E, K166R, D177E, R211K, L228H |
| >pt7-t0| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI YQYMDDLYVESDLEIGQHRTKIEELRQHLWKWGFYTPDNKHQKEPPFHWM |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A | L10I, D60E, I62V, L63P, A71V, V77I |
| >pt7-t0| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIVGIGGFTKVRQYE QVPIEICGHKVIGTVLIGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |