Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt13 | pt13-t1 | Italy | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | NA |
| 2 | SQV | NA |
| 3 | 3TC+ D4T+ IDV | NA |
| 4 | D4T+ DDI+ EFV+ RTV | NA |
| 5 | D4T+ IDV+ RTV | NA |
| 6 | 3TC+ APV+ D4T+ DDI | NA |
| 7 | D4T+ DDI+ EFV+ LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82VA, I84V, L90M | L33F | L10I, I13V, L19I, N37D, K55KR, I62V, L63P, C67F, A71V, I72L, Q92R |
| >pt13-t1| codons 1-99 PQITLWQRPIVTVKIGGQIKEALLDTGADDTVFEEMDLPGRWKPKMIGGIGGFVRVRQYD QVPIEIFGHKVLGTVLVGPTPANVIGRNLMTRIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67DN, K70KR, L74LI, M184MI, T215TFIS | K219KE | Y181YC | K20KR, V35I, V118VI, K122KQ, S134SG, Q174E, F214L | N137ND |
| >pt13-t1| codons 1-230 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DQDFRKYTAFTIPGINDETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI CQYIDDLYVGSDLEIGQHRTKIEELRQHLLRWGLSTPDEKHQKEPPFLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |