<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
MZ-pt6 pt6-t1 Italy 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT NA
2 AZT+ DDI NA
3 AZT+ DDC NA
4 3TC+ AZT NA
5 3TC+ AZT+ SQV NA
6 3TC+ D4T+ IDV NA
7 D4T+ NFV+ NVP NA
8 D4T+ EFV+ NVP NA
9 ABC+ D4T+ IDV+ RTV NA
10 3TC+ ABC+ D4T+ LPV NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, V75M, M184V, L210W, T215Y K219KR G190S   K20R, K43E, E44A, V118I, K122E, D177DN, T200K, H208HY, L228I  
>pt6-t1| codons 1-230
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV
FAIKKKDSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI
YQYVDDLYVSSDLEIGQHRKKIEELRQYLWRWGFYTPDRKHQKEPPFIWM

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, V82A, L90M K43T L10I, K20R, E35D, M36I, K55R, L63P, A71V, Q92K  
>pt6-t1| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTILEDINLPGRWTPKIVGGIGGFMRVRQYD
QIPIEICGHKVIGTVLVGPTPANIIGRNLMTKIGCTLNF

References
Author Title Citation
Romano, L Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. JAIDS, 2002
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005