Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt6 | pt6-t0 | Italy | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | AZT+ DDI | NA |
| 3 | AZT+ DDC | NA |
| 4 | 3TC+ AZT | NA |
| 5 | 3TC+ AZT+ SQV | NA |
| 6 | 3TC+ D4T+ IDV | NA |
| 7 | D4T+ NFV+ NVP | NA |
| 8 | D4T+ EFV+ NVP | NA |
| 9 | ABC+ D4T+ IDV+ RTV | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LI, V75M, L210W, T215Y | K219N | K103KN, Y181C, G190E | K43E, E44A, V118I, K122E, V179G, T200K, R211K, L228H |
| >pt6-t0| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKDSTKWRKIMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIGI CQYMDDLYVESDLEIGQHRKKIEELRQHLWKWGFYTPDNKHQKEPPFHWM |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46MI, I54IV, V82A, L90M | K43KT | L10I, K20KR, E35D, M36I, N37ND, K55KR, L63P, Q92K |
| >pt6-t0| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTILEDIDLPGRWTPKIIGGIGGFVRVRQYD QIPIEICGHKAIGTVLVGPTPANIIGRNLMTKIGCTLNF |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |