Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt5 | pt5-t1 | Italy | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | AZT+ DDC | NA |
| 3 | AZT+ DDC+ SQV | NA |
| 4 | 3TC+ AZT+ SQV | NA |
| 5 | D4T+ RTV+ SQV | NA |
| 6 | D4T+ EFV+ IDV+ RTV | NA |
| 7 | D4T+ DDI+ LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | G73T | L10I, K20I, M36I, D60E, I62V, L63P, C67F, A71V |
| >pt5-t1| codons 1-99 PQITLWQRPIVTIKIGGQLIEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFVKVRQYE QVPIEIFGHKVITTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | K103N | K43N, K122E, T139M, S162Y, D177E, Q207E, R211K |
| >pt5-t1| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |