Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt11 | pt11-t0 | Italy | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | NA |
| 2 | AZT+ DDI+ NVP | NA |
| 3 | 3TC+ AZT+ IDV | NA |
| 4 | 3TC+ IDV+ SQV | NA |
| 5 | 3TC+ EFV+ SQV | NA |
| 6 | 3TC+ EFV+ NFV | NA |
| 7 | DDI+ NFV | NA |
| 8 | D4T+ NFV | NA |
| 9 | AZT+ DDC+ SQV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, V82A, L90M | K43KT | L10I, L63P, I66F, A71V, I72V |
| >pt11-t0| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTILEEMNLPGRWTPKIIGGIGGFIKVRQYD QIPIEFCGHKVVGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65KR, D67N, T69D, K70R, Q151QKLM, T215F | F116FY, K219KE | K101E, K103KN, Y181YC, G190A | V90I, A98S, K102R, K122KE, E169D, E194ED, G196E, Q207AE |
| >pt11-t0| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKRKNSDRWRKLVDFRELNKRTQDFWEIQLGIPHPSGLERNKSVTVLDVGDAYYSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILDPFRKQNPDIVI CQYMDDLYVASDLDIEQHRTKIEELREHLLRWGFFTPDEKHQKEPPFLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |