Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt4 | pt4-t1 | Italy | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | NA |
| 2 | AZT | NA |
| 3 | AZT+ DDC | NA |
| 4 | 3TC+ D4T | NA |
| 5 | 3TC+ D4T+ IDV | NA |
| 6 | 3TC+ D4T+ SQV | NA |
| 7 | 3TC+ D4T+ RTV+ SQV | NA |
| 8 | D4T+ DDI+ NFV | NA |
| 9 | D4T+ DDI+ EFV | NA |
| 10 | None | NA |
| 11 | D4T+ DDI+ RTV+ SQV | NA |
| 12 | D4T+ DDI+ LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46ML, I84V, L90M | L10I, K20R, E35D, M36I, K55KR, R57K, L63P, I64V, V77I |
| >pt4-t1| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGRWKPKLIGGIGGFIRVKQYD QIPVEICGHKAIGTVLIGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | K43KN, R83RS, V118I, D123E, Q197QR, I202V, R211K |
| >pt4-t1| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKSTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGRHRTKVEELRQHLLKWGFYTPDKKHQKEPPFLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |