<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
MZ-pt4 pt4-t1 Italy 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDI NA
2 AZT NA
3 AZT+ DDC NA
4 3TC+ D4T NA
5 3TC+ D4T+ IDV NA
6 3TC+ D4T+ SQV NA
7 3TC+ D4T+ RTV+ SQV NA
8 D4T+ DDI+ NFV NA
9 D4T+ DDI+ EFV NA
10 None NA
11 D4T+ DDI+ RTV+ SQV NA
12 D4T+ DDI+ LPV NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46ML, I84V, L90M   L10I, K20R, E35D, M36I, K55KR, R57K, L63P, I64V, V77I  
>pt4-t1| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGRWKPKLIGGIGGFIRVKQYD
QIPVEICGHKAIGTVLIGPTPVNVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T215Y       K43KN, V118I, D123E, Q197QR, I202V, R211K R83RS
>pt4-t1| codons 1-230
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKSTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGRHRTKVEELRQHLLKWGFYTPDKKHQKEPPFLWM

References
Author Title Citation
Romano, L Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. JAIDS, 2002
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005