Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt3 | pt3-t0 | Italy | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | AZT+ DDI | NA |
| 3 | AZT+ DDC | NA |
| 4 | AZT+ DDI+ IDV | NA |
| 5 | AZT+ IDV | NA |
| 6 | 3TC+ AZT+ SQV | NA |
| 7 | D4T+ RTV+ SQV | NA |
| 8 | D4T+ EFV+ NFV | NA |
| 9 | 3TC+ D4T+ NFV | NA |
| 10 | D4T+ DDI+ NFV | NA |
| 11 | D4T+ NVP+ RTV+ SQV | NA |
| 12 | D4T+ DDI+ NVP | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K103N, Y181C | V35I, K43Q, K122E, A158S, E169D, G196E, I202V, R211K |
| >pt3-t0| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILDPFRKQNPDIVI CQYMDDLYVGSDLEIEQHRTKVEELRQHLWKWGFYTPDKKHQKEPPFLWM |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | Q58E, G73S | I13V, I15V, K20T, R41K, D60E, Q61D, L63P, I64V, A71V, V77I, I93L |
| >pt3-t0| codons 1-99 PQITLWQRPLVTVKVGGQLTEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVREYE DIPVEICGHKVISTVLIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |