Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt28 | pt28-t0 | Italy | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | DDI | NA |
| 3 | AZT+ DDC | NA |
| 4 | AZT+ DDC+ IDV | NA |
| 5 | 3TC+ AZT+ SQV | NA |
| 6 | D4T+ DDI+ EFV+ NFV | NA |
| 7 | D4T+ EFV+ NFV | NA |
| 8 | D4T+ DDI+ RTV+ SQV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | K43T | L10I, E35D, M36I, N37D, L63P, A71V, I72V, T74TS, I93L |
| >pt28-t0| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDIDLPGRWTPKLIGGIGGFVKVRQYD QIPIEICGHKVVGSVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74LV, L210W, T215Y | L100LI, K103N | A98G | T27S, V35VI, E40F, K43E, D123E, I135T, H208F, R211EK | D185DG |
| >pt28-t0| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALIEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPGGIKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMGDLYVGSDLEIGQHRTKIEELRQFLWKWGFYTPDKKHQKEPPFLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |