<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
MZ-pt27 pt27-t1 Italy 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT NA
2 AZT+ DDC NA
3 3TC+ AZT+ RTV NA
4 3TC+ AZT+ IDV NA
5 D4T+ EFV+ NFV NA
6 3TC+ AZT+ RTV+ SQV NA
7 3TC+ AZT+ IDV NA
8 ABC+ AZT+ DDI NA
9 ABC+ AZT+ DDC NA
10 3TC+ ABC+ AZT NA
11 APV+ D4T+ DDC+ RTV NA
12 None NA
13 DDI+ LPV NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54IV, V82A L24I, L33F, G73GS L10I, K20R, E21ED, E35D, M36I, N37D, I62V, L63P, A71V  
>pt27-t1| codons 1-99
PQITLWQRPIVTIKIGGQLRDALIDTGADDTVFEDIDLPGRWKPKMIGGIGGFVKVRQYD
QVPIEICGHKVISTVLVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, Y115YF, M184MV, L210W, T215Y V75M, F77L     V21I, V35I, T39A, K43E, E44D, K49R, E53D, K101Q, V118I, K122E, E169D, G196E, D218E  
>pt27-t1| codons 1-230
PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALIEICAELEEDGKISRIGPDNPYNTPV
FAIKKKNSDKWRKLMDLRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAFFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTPEKKHQKEPPFLWM

References
Author Title Citation
Romano, L Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. JAIDS, 2002
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005