Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt41 | pt41-t1 | Italy | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | AZT+ DDI | NA |
| 3 | 3TC+ AZT | NA |
| 4 | 3TC+ D4T+ IDV | NA |
| 5 | D4T+ DDI+ IDV+ RTV | NA |
| 6 | 3TC+ D4T+ IDV+ RTV | NA |
| 7 | EFV+ IDV+ RTV | NA |
| 8 | 3TC+ AZT+ LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | G73S | L10I, I15V, L19V, K20I, L24F, M36I, L63P, H69K, A71V, I93L |
| >pt41-t1| codons 1-99 PQITLWQRPIVTIKVGGQVIEALFDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD QIPIEICGKKVISTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | V35I, E44D, A98S, K101Q, K122E, D123E, N175NY, D177DG, G196GE, R211K |
| >pt41-t1| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLQKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQYPGIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |