Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt40 | pt40-t1 | Italy | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | AZT+ DDC | NA |
| 3 | 3TC+ AZT | NA |
| 4 | 3TC+ AZT+ SQV | NA |
| 5 | 3TC+ AZT+ RTV | NA |
| 6 | D4T+ DDI+ NFV | NA |
| 7 | D4T+ NVP+ RTV+ SQV | NA |
| 8 | ABC+ APV+ D4T | NA |
| 9 | ABC+ D4T+ RTV+ SQV | NA |
| 10 | ABC+ D4T | NA |
| 11 | ABC+ D4T+ LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V, I84V, L90M | F53L | L10I, I15V, G16E, K20I, Q61H, L63S, H69K, A71V, V77I, I85V |
| >pt40-t1| codons 1-99 PQITLWQRPIVTIKVEGQLIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGLIKVRQYD HISIEICGKKVIGTVVIGPTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | F77L, K219R | G190GA | K101KHNQ | V35L, K43Q, E44D, L109I, V118I, K122E, D123E, I135T, G196E, H208Y, R211K, D218E |
| >pt40-t1| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKLMDLRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVIDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVASDLEIEQHRTKIEELRQYLWKWGFYTPERKHQKEPPFLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |