<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
MZ-pt40 pt40-t1 Italy 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT NA
2 AZT+ DDC NA
3 3TC+ AZT NA
4 3TC+ AZT+ SQV NA
5 3TC+ AZT+ RTV NA
6 D4T+ DDI+ NFV NA
7 D4T+ NVP+ RTV+ SQV NA
8 ABC+ APV+ D4T NA
9 ABC+ D4T+ RTV+ SQV NA
10 ABC+ D4T NA
11 ABC+ D4T+ LPV NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, L76V, I84V, L90M F53L L10I, I15V, G16E, K20I, Q61H, L63S, H69K, A71V, V77I, I85V  
>pt40-t1| codons 1-99
PQITLWQRPIVTIKVEGQLIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGLIKVRQYD
HISIEICGKKVIGTVVIGPTPVNVVGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y V75M, F77L, K219R G190GA K101KHNQ V35L, K43Q, E44D, L109I, V118I, K122E, D123E, I135T, G196E, H208Y, R211K, D218E  
>pt40-t1| codons 1-230
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELEQDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLMDLRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVIDVGDAYFSIPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVASDLEIEQHRTKIEELRQYLWKWGFYTPERKHQKEPPFLWM

References
Author Title Citation
Romano, L Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. JAIDS, 2002
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005