Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt22 | pt22-t1 | Italy | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | DDI+ SQV | NA |
| 3 | 3TC+ D4T+ RTV | NA |
| 4 | D4T+ NFV+ NVP | NA |
| 5 | DDI+ IDV+ NFV | NA |
| 6 | IDV+ NVP+ RTV | NA |
| 7 | DDI+ IDV+ RTV | NA |
| 8 | D4T+ DDI+ LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | F53L, Q58QE | L10I, L19LI, M36V, N37E, K55KR, R57RK, I62V, L63P, A71V, T74TS, V77I |
| >pt22-t1| codons 1-99 PQITLWQRPIVTIKIGGQIKEALLDTGADDTVLEEVELPGRWKPKMIGGIGGLVRVKEYD QVPIEICGHKVIGSVLIGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215Y | K103N, Y181C | K122E, I135L, Q174QR, T200K | L26LF |
| >pt22-t1| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPFTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI CQYMDDLYVGSDLEIGQHRKKIEELRQHLLRWGFYTPDKKHQKEPPFLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |