Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
MZ-pt22 | pt22-t0 | Italy | 2000 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | AZT | NA |
2 | DDI+ SQV | NA |
3 | 3TC+ D4T+ RTV | NA |
4 | D4T+ NFV+ NVP | NA |
5 | DDI+ IDV+ NFV | NA |
6 | IDV+ NVP+ RTV | NA |
7 | DDI+ IDV+ RTV | NA |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
T215Y | K103N, Y181C | K122E, I135L, T200K |
>pt22-t0| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRKKIEELRQHLLRWGFYTPDKKHQKEPPFLWM |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
I54V, V82A, L90M | F53L | L10I, K20R, E35D, M36V, N37E, I62V, L63P, A71V, T74S, V77VI |
>pt22-t0| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDVELPGRWKPKMIGGIGGLVKVRQYD QVPIEICGHKVIGSVLIGPTPANIIGRNLMTQIGCTLNF |
References
Author | Title | Citation |
Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |