Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt20 | pt20-t0 | Italy | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | AZT+ DDI | NA |
| 3 | AZT+ DDC+ SQV | NA |
| 4 | 3TC+ AZT+ SQV | NA |
| 5 | 3TC+ D4T+ RTV | NA |
| 6 | D4T+ RTV+ SQV | NA |
| 7 | D4T+ DDI+ EFV+ NFV | NA |
| 8 | D4T+ DDI+ IDV+ RTV | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, L210W, T215Y | K219R | K103N | V108I | S48T, V118VI, K122E, I135T, S162C, I178M, G196E, T200I, E203K, R211K, K223E |
| >pt20-t0| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKITKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIEQHRIKIKELRQHLWKWGFYTPDRKHQEEPPFLWM |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, V82A, L90M | L10I, L63P, I64L, A71V, T74S, V77I, I93L |
| >pt20-t0| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIVGIGGFIKVRQYD QIPLEICGHKVIGSVLIGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |