Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1264 | CA3036 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 17 |
| 2 | 3TC+AZT+SQV | 70 |
| 3 | 3TC+AZT+NFV | 18 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, L90M | K43T | I13V, I15V, K20T, E35D, M36MI, L63P, I64V, T91TI |
| >CA3036| codons 1-99 PQITLWQRPLVTVKVGGQLTEALLDTGADNTVLEDINLPGRWTPKMIGGIGGFIKVRQYD QIPVEICGHKAIGTVLVGPTPVNIIGRNLMIQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | L74LF | V35R, T69TS, R83K, L100LF, I135V, Q207E, V245E, A272P, K277R, T286A, E297K | R72RG, N81NY, Q85QP |
| >CA3037| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICTEMEKEGKISKIGPENPYNTPV FAIKKKDSSKWGKFVDFRELYKKTPDFWEVQLGIPHPAGFKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE LEL |
References
| Author | Title | Citation |
| Zolopa, AR | HIV-1 genotypic resistance patterns predict response to saquinavir/ritonavir in patients in whom previous protease inhibitor therapy failed. | Ann Intern Med, 1999 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |