Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt38 | pt38-t1 | Italy | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | DDI | NA |
| 3 | D4T+ DDI | NA |
| 4 | D4T | NA |
| 5 | D4T+ RTV | NA |
| 6 | 3TC+ D4T+ IDV | NA |
| 7 | D4T+ DDI+ NFV | NA |
| 8 | None | NA |
| 9 | 3TC+ ABC+ APV | NA |
| 10 | D4T+ DDI+ LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A, L90M | L33F, K43T, G73S, L89V | I15V, K20R, E35D, M36I, N37E, K55R, R57K, L63P, A71V, I93L |
| >pt38-t1| codons 1-99 PQITLWQRPLVTIKVGGQLREALLDTGADDTIFEDIELPGRWTPKIVGGIGGFMRVKQYD QIPIEICGHKVISTVLVGPTPANIIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Q151M | V75I, F77L, F116Y | Y181CF | V35I, S68G, E79D, R83K, V118I, D121Y, K122E, S162C, S163A, I178M, Q197E, T200A, R211AT, F214L |
| >pt38-t1| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKRKDGTKWRKLIDLRDLNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSIPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQCAMTKILEPFRKQNPDMVI FQYMDDLYVGSDLEIGEHRAKIEELRQHLLTWGLTTPDKKHQKEPPFLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |