<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
MZ-pt38 pt38-t0 Italy 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 52
2 DDI 52
3 D4T+DDI 52
4 D4T 52
5 D4T+RTV 52
6 3TC+D4T+IDV 52
7 D4T+DDI+NFV 104
8 3TC+ABC+APV 52

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, Q151M V75I, F77L, F116Y     S68G, T69I, E79D, V118VI, D121Y, K122E, S162C, I178M, Q197E, T200A, E204D, R211T, F214L  
>pt38-t0| codons 1-230
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKRKDGIKWRKLIDLRDLNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSIPL
YEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQCSMTKILEPFRKQNPDMVI
YQYMDDLYVGSDLEIGEHRAKIEDLRQHLLTWGLTTPDKKHQKEPPFLWM

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, V82A, L90M L89V I15V, K20R, E35D, M36I, N37E, K55R, R57K, L63P, A71V, I93L  
>pt38-t0| codons 1-99
PQITLWQRPLVTIKVGGQLREALLDTGADDTILEDIELPGRWKPKIIGGIGGFIRVKQYD
QIPIEICGHKVIGTVLVGPTPANIIGRNVMTQLGCTLNF

References
Author Title Citation
Romano, L Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. JAIDS, 2002
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005