Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt38 | pt38-t0 | Italy | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | DDI | 52 |
| 3 | D4T+DDI | 52 |
| 4 | D4T | 52 |
| 5 | D4T+RTV | 52 |
| 6 | 3TC+D4T+IDV | 52 |
| 7 | D4T+DDI+NFV | 104 |
| 8 | 3TC+ABC+APV | 52 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Q151M | V75I, F77L, F116Y | S68G, T69I, E79D, V118VI, D121Y, K122E, S162C, I178M, Q197E, T200A, E204D, R211T, F214L |
| >pt38-t0| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKRKDGIKWRKLIDLRDLNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSIPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQCSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGEHRAKIEDLRQHLLTWGLTTPDKKHQKEPPFLWM |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, V82A, L90M | L89V | I15V, K20R, E35D, M36I, N37E, K55R, R57K, L63P, A71V, I93L |
| >pt38-t0| codons 1-99 PQITLWQRPLVTIKVGGQLREALLDTGADDTILEDIELPGRWKPKIIGGIGGFIRVKQYD QIPIEICGHKVIGTVLVGPTPANIIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |