Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MZ-pt37 | pt37-t1 | Italy | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | AZT+ DDI | NA |
| 3 | AZT+ DDC | NA |
| 4 | 3TC+ D4T+ IDV | NA |
| 5 | D4T+ IDV+ NVP | NA |
| 6 | D4T+ NFV+ NVP+ SQV | NA |
| 7 | D4T+ EFV+ IDV+ RTV | NA |
| 8 | APV+ D4T+ DDI+ RTV | NA |
| 9 | 3TC+ DDI+ LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, L90M | L10F, G73T | K20I, E35D, M36I, N37D, I62V, L63P, I64V, A71V, P79A, Q92K |
| >pt37-t1| codons 1-99 PQITLWQRPFVTIKIGGQLIEALLDTGADDTVLEDIDLPGRWKPKIIGGVGGFIKVRQYD QVPVEICGHKVITTVLVGATPVNIIGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_SS, L74V, L210W, T215Y | K103N, Y181C, G190A | V108VI | V35I, W88C, V118I, K122E, T139K, F171Y, R211K, H221Y |
| >pt37-t1| codons 1-230 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKDSSKWRKVVDFRELNKRTQDFCEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNEKPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPYRKQNPDIVI CQYMDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTPDKKYQKEPPFLWM |
References
| Author | Title | Citation |
| Romano, L | Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice. | JAIDS, 2002 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |