Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1260 | CA3029 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 130 |
| 2 | AZT+DDC | 26 |
| 3 | DDI | 30 |
| 4 | Unknown | 57 |
| 5 | 3TC+AZT | 13 |
| 6 | 3TC+AZT+SQV | 26 |
| 7 | 3TC+D4T+SQV | 61 |
| 8 | 3TC+D4T+NFV | 2 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, L90M | L10I, L38LF, L63P, A71AV, V77I, I93L |
| >CA3029| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNFPGRWKPKMIVGIGGFVKVRQYD QIPIEICGHKVIGTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219Q | Y188L | V35M, T39A, K49R, K64HY, V118I, D123E, S162D, T165I, E169D, D177E, V179I, G196E, I202V, Q207H, R211K, F214L, D218E, L228H, A272P, T286A, E297K | K13KN |
| >CA3028| codons 1-298 PISPIETVPVKLNPGMDGPKVKQWPLTEEKIKALMEICAEMEKEGKISRIGPENPYNTPV FAIHKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMIKILDPFRKQNPEIII YQYVDDLLVGSDLEIEQHRTKVEELRHHLLKWGLFTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKE |
References
| Author | Title | Citation |
| Zolopa, AR | HIV-1 genotypic resistance patterns predict response to saquinavir/ritonavir in patients in whom previous protease inhibitor therapy failed. | Ann Intern Med, 1999 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |