<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TVSP21 TVSP21 Brazil 1999 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 AZT 130
2 AZT+ DDI 43
3 AZT+ 3TC 17
4 D4T+ 3TC 13
5 3TC+ RTV+ D4T 13
6 D4T+ 3TC 17
7 IDV+ D4T+ 3TC 35
8 D4T+ 3TC+ NFV 43

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V       V35T, T39N, E40D, D123E, E169D, K173A, Q174K, Q207E, H208Y, R211K, V245Q, E248D, A272P, V276T, T286A, E291D, V292I, I293V, P294T, E297A, D324E  
>TVSP21| codons 1-324
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNDMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRAKNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELREYLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKTKQLCKLLRGAKALTDIVTLTAEAE
LELAENREILKEPVHGVYYDPSKE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15V, E35D, M36I, R41K, Q61N, K70R, I72T, L89M  
>TVSP21| codons 1-99
PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
NILIEICGHRATGTVLVGPTPVNIIGRNMLTQIGCTLNF

References
Author Title Citation
Brindeiro, PA Testing genotypic and phenotypic resistance in human immunodeficiency virus type 1 isolates of clade B and other clades from children failing antiretroviral therapy. J Clin Microbiol, 2002
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005