Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TVSP21 | TVSP21 | Brazil | 1999 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 130 |
| 2 | AZT+ DDI | 43 |
| 3 | AZT+ 3TC | 17 |
| 4 | D4T+ 3TC | 13 |
| 5 | 3TC+ RTV+ D4T | 13 |
| 6 | D4T+ 3TC | 17 |
| 7 | IDV+ D4T+ 3TC | 35 |
| 8 | D4T+ 3TC+ NFV | 43 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, E35D, M36I, R41K, Q61N, K70R, I72T, L89M |
| >TVSP21| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD NILIEICGHRATGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | V35T, T39N, E40D, D123E, E169D, K173A, Q174K, Q207E, H208Y, R211K, V245Q, E248D, A272P, V276T, T286A, E291D, V292I, I293V, P294T, E297A, D324E |
| >TVSP21| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNDMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRAKNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREYLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKTKQLCKLLRGAKALTDIVTLTAEAE LELAENREILKEPVHGVYYDPSKE |
References
| Author | Title | Citation |
| Brindeiro, PA | Testing genotypic and phenotypic resistance in human immunodeficiency virus type 1 isolates of clade B and other clades from children failing antiretroviral therapy. | J Clin Microbiol, 2002 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |