Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TVSP24 | TVSP24 | Brazil | 1999 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 19 |
| 2 | 3TC+AZT | 47 |
| 3 | 3TC+D4T | 28 |
| 4 | D4T+DDI+RTV | 1 |
| 5 | 3TC+D4T+NFV | 1 |
| 6 | Unknown | 26 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| Q18L, N37E, R57K, L63P, V77I, I93L | G17S |
| >TVSP24| codons 1-99 PQITLWQRPLVTIKIGSLLKEALLDTGADDTVLEEMELPGRWKPKMIGGIGGFIKVKQYD QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V, T215F | K49R, I135V, S162C, E169D, K173A, Q174K, T200A, Q207E, R211K, V245Q, E248D, K277R, T286A, V292I, I293V, E297A, S322A |
| >TVSP24| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRAKNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEIVPLTAEAE LELAENREILKEPVHGVYYDPAKD |
References
| Author | Title | Citation |
| Brindeiro, PA | Testing genotypic and phenotypic resistance in human immunodeficiency virus type 1 isolates of clade B and other clades from children failing antiretroviral therapy. | J Clin Microbiol, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |