Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JPN25 | JPN25 | Japan | 2000 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI+ AZT | 36 |
| 2 | AZT+ 3TC | 49 |
| 3 | AZT+ 3TC+ NFV | 25 |
| 4 | DDI+ D4T+ NFV | 48 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | A98G | E6D, K11T, V35T, T39K, K43E, E44D, V118I, D123N, I135T, K173I, Q174K, D177E, T200K, K201I, E204EV, Q207A, H208Y, R211N, K238R, V245E |
| >JPN25| codons 1-253 PISPIDTVPVTLKPGMDGPKVKQWPLTEEKIKALTEICKELEEDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DKNFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEIVI YQYMDDLYVGSDLEIGQHRKIIEVLRAYLWNWGFYTPDKKHQKEPPFLWMGYELHPDRWT VQPIELPEKDSWT |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, N88S | L10F, L33I, Q58QE, L89V | I13V, K20T, E35D, M36I, R41K, I62IV, H69K |
| >JPN25| codons 1-99 PQITLWQRPFVTVKIGGQLTEALLDTGADDTVIEDINLPGKWKPKIIGGIGGFIKVREYD QVLIEICGKKAIGTVLVGPTPVNIIGRSVLTQIGCTLNF |
References
| Author | Title | Citation |
| Ariyoshi, K | Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. | JAIDS, 2003 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |