Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JPN41 | JPN41B | Japan | 2001 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 82 |
| 2 | DDC+ AZT | 2 |
| 3 | IDV+ AZT | 53 |
| 4 | SQV+ 3TC+ AZT | 25 |
| 5 | NFV+ 3TC+ D4T+ DDI+ AZT | 52 |
| 6 | NFV+ D4T+ DDC | 3 |
| 7 | NVP+ D4T+ DDI | 27 |
| 8 | None | 8 |
| 9 | AZT+ NVP | 5 |
| 10 | APV+ NVP+ AZT | 62 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82F, L90LM | L10I, I13V, G16E, K20I, E35DN, M36I, P39Q, R41K, K45V, G48X, I62V, L63P, H69K, L89M |
| >JPN41B| codons 1-99 PQITLWQRPIVTVKIEGQLIEALLDTGADDTVLEDINLQGKWKPVMIXGIGGFVKVRQYD QVPIEICGKKAIGTVLVGPTPFNIIGRNMMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, L210W, T215F | K219W | Y181C | V108I | E6D, K11KT, V35T, T39K, K43E, K122E, D123NS, I135L, S162C, R172K, K173I, Q174K, D177E, I178M, T200A, Q207A, R211RKNS, L228H |
| >JPN41B| codons 1-242 PISPIDTVPVTLKPGMDGPKVKQWPLTEEKIKALTEICKEMEEEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSVPL DESFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFKIKNPEMVI CQYMDDLYVGSDLEIGQHRAKIEELRAHLWSWGFFTPDWKHQKEPPFHWMGYELHPDKWT VQ |
References
| Author | Title | Citation |
| Ariyoshi, K | Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. | JAIDS, 2003 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |