Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JPN40 | JPN40B | Japan | 2000 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 45 |
| 2 | AZT+ DDC | 14 |
| 3 | AZT+ DDC+ IDV | 35 |
| 4 | 3TC+ SQV+ AZT | 29 |
| 5 | D4T+ 3TC+ NFV | 114 |
| 6 | ABC+ EFV+ NFV | 22 |
| 7 | NFV+ 3TC+ D4T | 18 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10LF | T12A, I13V, I15IV, E35D, M36I, R41K, R57K, I64IV, H69K, L89M |
| >JPN40B| codons 1-99 PQITLWQRPFVAVKVGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD QILVEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184MV | E6D, V8VI, K11T, V35T, T39K, K43E, K49KR, T69TN, K122KE, D123NS, I135T, K173I, Q174K, D177E, I178M, T200E, Q207A, R211K, K238KR, I244IV, V245E |
| >JPN40B| codons 1-266 PISPIDTIPVTLKPGMDGPKVKQWPLTEEKIKALTEICKEMEEEGKISRIGPENPYNTPV FAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEMVI YQYVDDLYVGSDLEIGQHREKIEELRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDRWT VQPVELPEKDSWTVNDIQKLVGKLNW |
References
| Author | Title | Citation |
| Ariyoshi, K | Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. | JAIDS, 2003 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |