Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JPN9 | JPN9B | Japan | 1999 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ 3TC | 8 |
| 2 | AZT+ DDI | 8 |
| 3 | AZT+ 3TC | 92 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | V35T, T39K, K43E, S68G, K122E, D123NS, K173I, Q174K, D177E, I178M, Q207A, R211S, K238R |
| >JPN9B| codons 16-240 MDGPKVKQWPLTEEKIKALTEICKEMEEEGKISKIGPENPYNTPVFAIKKKDGTKWRKLV DFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSI NNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEMVIYQYVDDLYVGSDLEI GQHRTKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDRWT |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46ML | K20R, E35D, M36I, R41K, I62MT, L63P, H69K, L89M | K45KE |
| >JPN9B| codons 1-99 PQITLWQRPLVTIKIGGQLREALLDTGADDTVLEDINLPGKWKPELIGGIGGFIKVRQYD QMPIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Ariyoshi, K | Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. | JAIDS, 2003 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |