Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JPN39 | JPN39 | Japan | 2000 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 34 |
| 2 | D4T | 59 |
| 3 | AZT+ NFV | 25 |
| 4 | 3TC+ NFV+ AZT | 175 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, N88S | L10F | I13V, K20I, E35D, M36I, R41RK, I64V, H69K, T74S, V77VI, L89M, I93L |
| >JPN39| codons 1-99 PQITLWQRPFVTVKIGGQLIEALLDTGADDTVLEDINLPGKWKPKIIGGIGGFIKVRQYD QILVEICGKKAIGSVLIGPTPVNIIGRSMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219Q | E6D, K11T, V35T, T39K, K43E, T69TN, K102E, K122E, D123S, I135IV, S162Y, K173R, Q174K, D177E, T200A, Q207A, R211A, K238R, V245K |
| >JPN39| codons 1-266 PISPIDTVPVTLKPGMDGPKVKQWPLTEEKIKALTEICKEMEEEGKISKIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKEKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRRKNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELRAHLLAWGFTTPDQKHQKEPPFLWMGYELHPDRWT VQPIKLPEKDSWTVNDIQKLVGKLNW |
References
| Author | Title | Citation |
| Ariyoshi, K | Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. | JAIDS, 2003 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |