Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JPN38 | JPN38 | Japan | 2000 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | IDV+ DDI+ AZT | 125 |
| 2 | AZT+ 3TC+ NFV | 4 |
| 3 | AZT+ DDI | 4 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | E6D, V8I, K11T, V35T, T39K, K43E, V118VI, K122E, D123S, K173I, Q174K, D177E, V179I, Q207A, R211S, K238R, V245E | R78RI |
| >JPN38| codons 1-258 PISPIDTIPVTLKPGMDGPKVKQWPLTEEKIKALTEICKELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFIELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEIII YQYMDDLYVGSDLEIGQHRTKIEELRAHLWSWGFYTPDKKHQKEPPFLWMGYELHPDRWT VQPIELPEKDSWTVNDIQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82F | L10I, I13V, G16E, K20I, E35D, M36I, R41K, K45V, L63LH, H69K, K70R, L89M, F99FL |
| >JPN38| codons 1-99 PQITLWQRPIVTVKIEGQLIEALLDTGADDTVLEDINLPGKWKPVMIGGIGGFVKVRQYD QIHIEICGKRAIGTVLVGPTPFNIIGRNMLTQIGCTLNL |
References
| Author | Title | Citation |
| Ariyoshi, K | Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. | JAIDS, 2003 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |