<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
JPN35 JPN35 Japan 2000 HIV1 CRF01_AE Plasma None

Treatment History
Order Regimen Weeks
1 AZT 10
2 AZT+ 3TC 70
3 IDV+ AZT+ 3TC 17
4 D4T+ 3TC+ NFV 123

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67DN, T69AD, M184V, L210LW, T215F       E6D, K20R, V35T, E36ED, T39R, K43E, E44D, K102MR, K104R, K122E, D123S, S162Y, K173T, Q174K, D177E, Q207A, R211S, K238R, V245K  
>JPN35| codons 1-253
PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALTDICRELEEDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKRSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRTKNPEIVI
YQYVDDLYVGSDLEIGQHRTKIEELRAHLWSWGFFTPDKKHQKEPPFLWMGYELHPDRWT
VQPIKLPEKDSWT

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, L90M   L10V, I13V, K20T, E35D, M36I, R41K, Q61H, L63P, I64V, H69K, K70R, T74S, R87X, L89M, I93L  
>JPN35| codons 1-99
PQITLWQRPVVTVKIGGQLTEALLDTGADDTVLEDINLPGKWKPKIIGGIGGFIKVRQYD
HIPVEICGKRAIGSVLVGPTPVNIIGXNMMTQLGCTLNF

References
Author Title Citation
Ariyoshi, K Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. JAIDS, 2003
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005