Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JPN35 | JPN35 | Japan | 2000 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 10 |
| 2 | AZT+ 3TC | 70 |
| 3 | IDV+ AZT+ 3TC | 17 |
| 4 | D4T+ 3TC+ NFV | 123 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, T69AD, M184V, L210LW, T215F | E6D, K20R, V35T, E36ED, T39R, K43E, E44D, K102MR, K104R, K122E, D123S, S162Y, K173T, Q174K, D177E, Q207A, R211S, K238R, V245K |
| >JPN35| codons 1-253 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALTDICRELEEDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKRSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRTKNPEIVI YQYVDDLYVGSDLEIGQHRTKIEELRAHLWSWGFFTPDKKHQKEPPFLWMGYELHPDRWT VQPIKLPEKDSWT |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | L10V, I13V, K20T, E35D, M36I, R41K, Q61H, L63P, I64V, H69K, K70R, T74S, R87X, L89M, I93L |
| >JPN35| codons 1-99 PQITLWQRPVVTVKIGGQLTEALLDTGADDTVLEDINLPGKWKPKIIGGIGGFIKVRQYD HIPVEICGKRAIGSVLVGPTPVNIIGXNMMTQLGCTLNF |
References
| Author | Title | Citation |
| Ariyoshi, K | Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. | JAIDS, 2003 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |